Drugs that May Interact with CBD Oil
CBD oil interacts with certain prescription medications, which is why you should always consult your doctor before using cannabidiol.
Written by Cathy Rozyczko
Edited by Cathy Rozyczko on
September 14, 2021
CBD Oil Drug Interactions – The CYP450 Pathway
Research has begun to demonstrate that cannabidiol (CBD) has the potential to effectively help a large number of people. CBD oil interacts with the endocannabinoid system in a way that produces very few unintended side-effects.
While the majority of the vast majority of the science indicates CBD oil is safe for use and consumption, it does pose a few risks that, if not properly understood, could be dangerous.
One of these risks is the inhibition of the cytochrome P450 enzyme system.
What is the Cytochrome P-450 System?
Found within the liver, the cytochrome P450 enzyme system is responsible for metabolizing potentially toxic compounds, including over 60% percent of any drugs you have consumed.
According to Davis’s Drug Guide, this system contains more than 50 enzymes that process and eliminate toxins.
Why Does CYP450 Matter?
In order to determine the appropriate dosages of medications, doctors make calculations using the average amount of time it takes for various drugs and medications to be processed through the cytochrome P450 system.
If only one drug is being processed, and the system is generally healthy, these averages provide accurate dosage information.
However, certain substances have the ability to affect processing times within this system, making drugs metabolize faster or slower than they would on their own.
Similarly, if the cytochrome P450 system is unhealthy due to problems with the liver or other pre-existing conditions, drugs may not metabolize as they should.
Cannabidiol in the Cytochrome P-450 System
Cannabidiol can inhibit the cytochrome P450 system’s ability to metabolize certain drugs, leading to an overall increase in processing times.
Interestingly, CBD oil is not alone in its effect on drug metabolism. Grapefruit, watercress, St. John’s Wort, and goldenseal all have a similar impact in terms of CYP450 inhibition.
When the CYP450 system is impacted in this way, it leads to higher levels of certain drugs in your system at one time. This can cause unwanted side effects, and sometimes, an overdose.
If you are taking a medication affected by cannabidiol, you should consult your doctor to make sure that it is safe for you to supplement your personal care routine with CBD oil. From there, the two of you may consider adjusting the dosage on your medications so that you can use both products safely.
Drugs that Interact with Cannabidiol
Any drug metabolized by CYP450 enzymes could potentially interact with cannabidiol. According to the Indiana University Department of Medicine, drugs known to use the CYP450 system include:
- HMG CoA reductase inhibitors
- Calcium channel blockers
- HIV antivirals
- Immune modulators
- Beta blockers
- Angiotensin II blockers
- Oral hypoglycemic agents
This list does not include all of the potential medications impacted by cannabidiol. Nor will every medication in the categories contained on this list will cause an interaction. For these reasons, you should consult with a medical professional before supplementing with CBD oil.
There are certain medications, known as “prodrugs,” that need to be metabolized to produce the therapeutic compound. In other words, you ingest an inactive compound and once in the body, it is processed into the active drug. If this processing is dependent on CYP3A4 (part of the larger CYP450 system), then inhibitors can result in too little active drug in the body for the desired therapeutic effect.
Codeine, for example, is a prodrug that is metabolized into morphine which provides the effect.
Vyvanse and Concerta are two other popular pharmaceutical medications for ADHD that fall into this category.
If you are worried that your CYP450 pathway may not be functioning properly, physicians can test the system to ensure that the medications you take are metabolizing as expected.
Combining Alcohol and CBD Oil
Alcohol and cannabis are both widely consumed in our society and the effects of combining the two are well known.
What is less understood by the general public, is the effects of combining alcohol and the cannabinoid compound CBD.
Alcohol depends on a few different metabolic pathways in the human body, with the primary enzymes involved being:
In people who only drink socially or occasionally, ADH and ALDH handle the entire workload of metabolizing ethanol. However, when binge drinking (or during chronic consumption of alcohol) CYP450 gets involved to assist the overloaded ADH and ALDH pathways.
Here are some interesting tidbits about alcohol and CBD oil:
- The CB1 receptor is a significant player in the reinforcing and motivating attributes of alcohol. [S]
- Combining alcohol and CBD results in significantly lower blood levels of alcohol. [S]
- CBD reduces the reinforcement, motivation and relapse for alcohol. [S]
- CBD protects the liver from damage done by binge-drinking alcohol. [S]
- CBD prevents against alcohol-induced neurodegeneration. [S]
- CBD attenuates alcohol-induced liver steatosis, metabolic dysregulation, inflammation and neutrophil-mediated injury. [S]
- Cannabinoids have an effect on nearly all enzymes responsible for metabolizing alcohol. [S]
- CB1 receptor agonists (THC) encourage alcohol consumption, while CB1 receptor antagonists (CBD) decrease it. [S]
Although the pharmacokinetics of alcohol and CBD are not yet well-understood, what we do know is CBD inhibits the CYP450 enzyme system, and this system plays a significant role in alcohol metabolism.
Additionally, as found in mice, CBD alters levels of ADH and ALDH to varying degrees.
It is important to be mindful and cautious when mixing CBD and alcohol.
Caffeine and CBD – Better than a PB&J
Caffeine is the world’s most famous and commonly consumed psychoactive drug. Who doesn’t ingest even a little from time to time?
CBD oil is rapidly gaining ground on coffee in terms of popularity and so it only makes sense that people would start combining the two.
As it turns out, the two substances go very well together!
Caffeine is molecularly very similar to adenosine, a compound produced in our bodies that activates the A2a receptor. Caffeine binds to the A2a receptors, inhibiting the reuptake of adenosine.
When adenosine binds to the A2a receptor, the result is what is commonly known as the ‘rest and digest’ effect. It helps us to calm down and relax. Because caffeine inhibits adenosine from binding to its receptors, it increases clarity and alertness.[S]
Similarly, CBD oil also binds to the A2a receptor, blocking the reuptake of adenosine.[S] So the theory goes that by combining caffeine and CBD, adenosine is blocked across the board, resulting in not only more stimulation, but reduced anxiety (due to CBD’s effects on other neurotransmitters systems).
It is worth noting that these effects depend on the serving size of the CBD. High amounts of CBD are more likely to cause drowsiness and sedation.
Additionally, caffeine is metabolized by a CYP450 enzyme, specifically CYP1A2. As CBD inhibits the CYP450 enzyme system, a slowed excretion rate of caffeine will occur. This can mean the effects of the caffeine will be more prolonged and drawn out. The can be both good and bad!
On the bright side, CBD oil and caffeine together will cause the boost from your morning cup of coffee to last all day instead of just a few hours. On the downside, it’s easy to overdo it and end up wide-eyed in bed when you are trying to go to sleep.
Considering this information, again, it is best to be mindful and cautious when mixing caffeine and CBD.
Can CBD Oil Be Addictive?
One of the most common questions we get is: Can I get addicted to CBD oil? The answer depends on what you mean by “addicted.”
When looking at the chemical impacts of CBD oil, the answer is no. Cannabidiol is not physically addictive in the same way opiates, cocaine, alcohol, and other drugs can be. Also, CBD oil does not produce any physical withdrawal symptoms when you stop using it. In fact, CBD oil is currently being researched as a potential tool for minimizing the severe withdrawal from drugs like opiates.
But, having said that, human beings can get addicted to just about anything including exercise, music, sex, and food.
Because CBD oil can alter essential liver enzymes, it is crucial to do your research, talk to your physician, and figure out how to best consume CBD oil for your specific situation.
Information and education will be your most powerful weapons going forward.
How To Use CBD Oil
When taking cannabidiol, it is important to consume only the recommended serving size.
Raising or lowering this amount may produce the opposite of the desired effect.
Keep in mind that some people may metabolize cannabidiol differently because of anomalies within the cytochrome P45O (CYP450) enzyme system. And depending on when you take your medications, you may find an unintended increase or decrease in CBD concentrations in your blood.
If you suspect that you are not metabolizing CBD oil as expected, ask your doctor to test your cytochrome P450 enzyme system before adjusting your dosage.
Also, you may refer to our page on dosing CBD oil for additional information.
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You ’re the bold person I know! I wish I was more like you.
I appreciate you sharing this blog post. Thanks Again. Cool.
I have portal vein thrombosis of unknown cause. I am on Xarelto for life. Can I use CBD oil?
I also take modafinl, recently I withdrawled from Alpralazam in 12 days wit the help of 10 mg of cbd. There is a co-relationship between small amounts of cbd.The receptors in the brain for some reason are more conducise to smaller amount of cbd, larger amounts are disregarded, in some situations. I take 30 mg. of modifinil and 40 mg. of Vynanse. but the most important ingredient is t get yourself into a workout program to generate the necessary amount of energy, which will be stored until called upon. Believe this does work.I had prostrate surgery, and I had to find a means to replace the energy from another source.
has anyone ever taken CBD oil with Nifedepine Blood pressure meds and was it ok?
I had a group member comment in a share:
I not understand if cbd is an inhibitor for palbocyclib or not
My TSH improved after taking CBD for one week.
Is it safe to continue drinking 1 bottle of CBD water per day and take levothyroxine?
take less cbd or take it earlier
I’m not that far yet. My hubby has lupus and is on a beta blocker. He’s had no problems with cbd doing that to him. We see the cardiologist and I get sooo many questions about this I’ll have his answer soon. He’s been on it 4 months and there have been no issues so I’m so sorry this is happening
Cbd is a natural blood thinner. So I know doctors that have seen cbd lower amount of warfarin that’s needed. Run it by him first Bc the correct mg and dosage of cbd will help use less oxy which is probably making them feel really really bad. Cbd is a great pain killer. More and more patients are asking their preference of cbd consumption to their doc made known
Why? My husband has been on prednisone for 2 years with lupus taking cbd. No problems. Finally they are taking him off. Coming down little by little. The withdrawals are awful but hey, my husbands been doing it. The point to remember is take your prednisone and cbd 2 hours apart. So at night he takes it at 8:30pm and cbd right before he goes to bed at 11pm.
Absolutely yes! By me husbands dr. He has lupus and takes his plaquenil every day and is on 750mg 5 drops ea AM and 5 drops ea PM
My husband has lupus so thankfully we are after a year coming off prednisone. Yes you can take it but here’s the deal .. take your meds and cbd 2 hrs apart. Whichever you take first is fine just separate the meds from the cbd and it gives everything taken a correct path to get to work. Hope you won’t be on prednisone too long. The withdrawals put my husband in the bed for 3 days… flu like symptoms and a fever. Cbd really got him through
I chew nicotine gum and take cbd. Cbd should be taken and always wait 20 minutes to do what’s next whether that’s drink, eat vape.
I use it in combo. I talked with my psychiatrist about it. I go through periods of insomnia. When that happens you can take them both at night. I personally take all my meds and supplements at 830pm and my cbd right at bedtime at 11pm.
Cbd oil when first starting is known to “detox” Most people get a slight headache. But the detox is over in 24 hrs. There are no side effects really to cbd
I could write a novel. Lol Just Google endocannibinoid system. It’ll talk about receptors and how CBD works with them. I’m glad when doctors are on board
I work with cbd oil users going to pain management. You MUST take THC FREE cbd or it will show up
Good for you! My husband has lupus and is finally getting off steroids. He was on them over a year. Cbd got him thru 3 days in bed … flu symptoms. Just awful. Don’t let them keep you on steroids too long. Cbd oil takes his pain away and he isn’t going on the anti transplant rejection freakin medication they want to put him on next. No more meds he says. Just CBD. And we take Hempworx
Depends on where you got it and what’s in it There’s a US Hemp seal of Approval list on cbd oil Only buy from that list. They are third party tested. There should be only 2 ingredients… hemp seed carrier oil and CBD. So many companies say Pure when it’s junk.
upping your dosage so quickly made you have diarrhea. You’ve got to go really slow to find the amount of drops that a right for you. And yes cbd is a natural blood thinner. Tell your doc you’re on it. My hubby has lupus. His rheumatologist told him to not take it bc it wasn’t fda approved. He told her I’m in no pain and feel more alive than I have in the last 5 months I’ve been taking it. So I’m not asking you I’m telling you so you can put it in your chart.
Tylenol is just terrible to take on a consistent basis. Would be good to have her off that and on a really good 1500mg cbd. Cbd is a natural pain killer. And you read that right. My dogs pet cbd is 250mg. I take 750mg myself. With her pain level she would do well off Tylenol codeine and on 1500mg cbd. No side effects. No drowsiness. Sleepiness. That’s what I’d do if she were my mom. 1500mg is what my cousin uses for his chronic arthritis. He doesn’t take any pain pills and hasn’t in 6 yrs on cbd.
Yes absolutely. It will help with any withdrawals. Sometimes coming off an anti anxiety med can cause you anxiety if that makes since. At least it did with me so I took my cbd at the same time. My husband finally came off prednisone for his lupus after being on it for 2 years. 3 days in bed withdrawing and cbd and Motrin to reduce the fever is what got him through. It was awful!
I’m not sure you should have started out on a high dosage 3000mg. Good Lord. My husband has lupus and is on 750mg 5 drops am and 5 drops pm. for his pain! Perhaps you should choose a brand that has the US Hemp seal of approval. That way you’ll know what’s in that bottle bc it’s third party tested Its important to know what’s in the bottle. Should only be 2 ingredients… hemp seed oil and carrier oil and cbd. That’s it. Seriously you’re taking way too high a dosage. And I was on provigal. Very helpful for staying awake for sleep apnea patience and chronic fatigue. I took it at 20mg a day to get me out of bed for severe depressive episode.
Yes for me personally I use cbd and my psychiatrist says it’s fine. He said many patients are on it too. It’s a supplement and should be taken an hour before or after meds.What I personally do is take my lexapro,Ativan,lamictal and topimax at 830pm every night. I usually dose 5 drops right at bedtime at 11pm.
Sounds like an allergic reaction.
Doctors make a hell of a lot more off of eliquis than CBD oil.
Please, stay away from Ambien. It is a devil drug and should be taken off the market. I am also under much pain and take Norco 10mg every 4-6 hours. Will speak to my doctor about CBD oil. Any relief is most welcome.
I too am on Norco’s (10 mg) for degenerative disc disease, arthritis in both hips and lower spine. I recently started on CBD oil and would love to come off the Norco’s completely.
I will of course speak to my doctor about this, but he is the one that actually pointed me to the CBD initially.
Any help or recommendations is greatly appreciated.
I have severe depression, anxiety, PTSD. I’ve been on the listed medications for 10 years plus. I am currently taking Klonopin, ambien, celexa, lamictal, saphris, wellbutrin and inderal. The medication just doesn’t seem to be adequate anymore. Can CBD be compatible with the above stated medicines. Can they help to get me off of some of the med’s. Thank you for your time.
I use Xanax and CBD with no problems. I am using CBD to treat intense pain while I am still going through testing for a variety of autoimmune diseases.
I smoke it. My dose is regulated in a pattern and it has allowed me to find a happy medium for myself. I smoke about 1-1.5 grams of CBD flow a day. The strain I use is the one that is right for me.
I take Tylenol, Mobic Cymbalta Flecanide Myrabetric Librax Estradiol!
I am on Synthroid,and my Dr recommended CBD oil,to help with mild anxiety.Ask your Dr.?
How are you feeling since taking CBD oil with the Zoloft? I have been on 50 mg of Zoloft for almost 3 years & planning to start adding in CBD oil. Feeling a little nervous though, but my doctor prescribed it.
Can you take CDP oil while taking 70 mg Oxicontin daily Asprin,6 Tradol plus 37.5mg,Arcoxia 90mg,Trental 400mg,Atorvas 40mg Lamicsl 50mg Thanks in advance
Very interesting and informative article pal!
I take losartan and I take CBD oil no problems so yes it should be okay to take with Losartan
That’s not true I take high cholesterol medicine and I take CBD oil no inner actions at all no issues whatsoever so go ahead it is safe to take CBD oil with cholesterol medicine
It will not interfere with blood pressure medicine it will not interfere with metformin I take blood pressure medicine and I take metformin and I also take my CBD oil no problems the other medicines I am not sure I would Google it but when the metformin and the blood pressure medicine I take blood pressure medicine and Metformin and I have had absolutely no issues at all
It should not interfere Google your question
I wouldn’t you should stop vaping it is very very dangerous
Make sure when you take CBD oil it is 100% pure CBD oil make sure it has no THC in it that’s why your skin was feeling the way it was 100% pure CBD oil I am a type 2 diabetic I am trying to wean myself off of my diabetes medicine so I can reverse my diabetes so please 100% pure CBD oil no THC
Make sure there’s 3 Rd party lab results and it’s a good reputable company. Start slow and work ur way up .look up microdosing for CBD and it will help you to find ur sweet spot. If u take to much it’s not doin anything for you less is more with cbd. I started with a 3000 mg bottle and take 8 drops only drops and it works great it’s only like 12 mg of CBD .always separate ur medication and CBD by two hours. Best of luck
Hi I took gabapentin, up to 600 mg per day, it didn’t to much for my pain hence the canibis oil.
I take 3 different BP meds, also metformin & mint glizacide for type 2 diabetes. I started taking cannabis oil about 1 month ago. I’m taking this for my sciatic, arthritis, & neuropathy pain. My doctor says it is ok to take up to x3 per day. I also take clonazepam for anxiety & to aid w/sleep @ night. I’M not ready to just take canibis, & not take the anxiety pill. I have had trouble falling off to sleep naturally for about 15 years. I need my sleep as I work early mornings. P/T.
I’ve used CBD oil, THC free, for a few years now with no side effects what so ever. I have had 4 spinal surgeries with the last being a spinal cord stimulator for pain. I also have Fibromyalgia, Rheumatoid Arthritis, plus a few other assorted ailments. I’ve suffered from severe chronic pain for several years now and am on many prescriptions, including oxycodone, which I have been able to keep at a low dosage with the help of CBD oil. It has also helped with my depression at times. I would definately speak with yur specialist prior to beginning on the therapy and use a reputable companyto get your CBD oil from where you can check their testing product location.
Hi I recently started taking 400mg of Vimpat daily and want to know how does cbd oil interact with Vimpat
Hi. Is it safe to take CBD oil while taking Humira!! I appreciate any help. 🙂
I would check with both a pharmacist and your Physician. Several of your medications are in direct conflict with another; essentially cancelling out the effect both medications beneficial effects.
I am not a Dr, just a Senior Citizen who also has multiple physical maladies. I have been through the Gamut of medications. Via many long years of trial/error of physicians basically “experimenting” to see what did and/or did not work.
After experiencing many Severe adverse side effects,
Or no effect at all due to the Dr prescribing medications that cancelled each other out.
Hopefully both you and myself, the CBD Oil will have the proper effect for Pain Management, Epilepsy Management, and PTSD.
All I know at this time is that the CBD Oil needs adjusted for enough effect to accomplish the desired effects of both My Physician and Myself.
If you stopped drinking fluoride, you might not need those thyroid drugs.
“According to the U.S. National Research Council, and as discussed below, there is substantial evidence that fluoride exposure can impact thyroid function in some individuals. (NRC 2006).
Fluoride Was Once Prescribed as an Anti-Thyroid Drug
When people think of fluoride being prescribed for medicinal purposes, they generally think of fluoride supplementation to reduce tooth decay. Fluoride, however, has also been prescribed as a drug to reduce the activity of the thyroid gland. Up through the 1950s, doctors in Europe and South America prescribed fluoride to reduce thyroid function in patients with over-active thyroids (hyperthyroidism). (Merck Index 1968). Doctors selected fluoride as a thyroid suppressant based on findings linking fluoride to goitre, and, as predicted, fluoride therapy did reduce thyroid activity in the treated patients. (McClaren 1969; Galletti 1958; May 1937). Moreover, according to clinical research, the fluoride dose capable of reducing thyroid function was notably low — just 2 to 5 mg per day over several months. (Galletti & Joyet 1958). This dose is well within the range (1.6 to 6.6 mg/day) of what individuals living in fluoridated communities are now estimated to receive on a regular basis. (DHHS 1991).
Fluoride & Hypothyroidism
Based on fluoride’s anti-thyroid effects in hyperthyroid patients, concerns have arisen about whether current fluoride exposures could be contributing to the increased prevalence of under-active thyroid (clinical and/or subclinical hypothyroidism) in the United States and other nations. In February 2015, British scientists reported that fluoridated water in Britain is associated with elevated rates of hypothyroidism:”
Unfortunately, not every doctor will be educated on CBD. One thing you can do is find a cannabis doctor online to schedule a consultation over the phone. Mind you, they will charge you a fee and most likely will not take insurance. They are licensed and will be able to answer most, if not all, of your questions.
Take your blood pressure. I take lisinopril 10mg and my blood pressure dropped real low 96 over 55 and it made me lightheaded. I stopped the cbd oil until my pressure goes back up.
What if your doctor is so dumb about hemp cbd oil that he is not able to answer your questions. Then what can you do? I take blood pressure medicine and my blood pressure dropped real low and I stopped the cbd oil. The oil helped my pain and help me sleep.
I just started taking CBD oil. I DO take Lisinopril and have for over a year. I am experiencing extreme lightheadedness and nausea. I reduced the amount of CBD this morning to only 3 drops of 1000 mg strength. Within minutes I was having a negative reaction. I had to lay down for 4 hours as it made me dizzy and nauseated.
Ambien is not a nice drug. You can be somnambulant while on it. Some people drive a car, make a meal, or do other things, during the night, and have no idea (the next morning) that they did then.
That’s directed toward the OP. Argelia.
Holy moly, that’s a lot of drugs.
Temazepam should only be used for about one week, for example.
Too many drugs being prescribed for them!
Please always check with your prescribing doctor for any medical advice.
Please always check with your prescribing doctor for any medical advice.
Please check with your physician for medical advice.
Please check with your physician for medical advice.
Please check with your physician for medical advice.
Please check with your physician for medical advice.
Please check with your physician for medical advice.
Please check with your physician for medical advice.
Please check with your physician for medical advise.
Please check with your physician for medical advice.
I take 30mg nifidipin, 1/2 tab. Of 25 mg spinolatone, 81 mg Bayer in am and 10 mg pravastatin, and other half of 25mg spinolatone in pm. Is it safe to use cbd oil with these medications ??
Is cbd oil compatible with brilanta.60 mg?
I had a multi-level back fusion with mixed results, and am still in constant pain. I have been taking Tramadol (which is an opioid) for many years with moderately good results. Recently I tried using CBD taken under the tongue. I found that when my daily dose of CBD reached about 10 milligrams per day, I would wake up in the middle of the night with excruciating radicular pain from my back to my feet.
This is apparently not typical, but I have met a few other “bad back people taking opioids” with similar complaints. I have researched that CBD shuts down certain liver enzymes (like CYP2D6 and other CYP450 family enzymes) that allow the liver to process Tramadol and many other meds to the metabolite form that actually relieves pain. So for my particular chemistry CBD was essentially blocking the pain relief from the Tramadol.
Recently I have experimented with vaped THC marijuana flowers which gives me about 5 hours of better-than-Tramadol pain relief from a single puff. The accompanying high is very mild, like an ounce or two of wine. This may be working for me due to the THC reaching my blood stream directly without having to go through my liver. In any case, the pain relief from vaping greatly exceeds the pain relief from taking essentially the same dose orally, even though the oral dose is more intoxicating. I’m not sure I will be able to completely stop using Tramadol this way, but this seems to offer a hopeful path. FWIW correctly dosing vaped cannabis is very tricky, best to get some coaching from an experienced vaper otherwise you will initially grossly overdose which will not kill you but may not be to your liking. I have also tried vaping CBD-only hemp flowers with essentially no results, would be interested to hear from others about their experiences with that…
I’m NOT a doctor and NOT into medicine so this is my opinion do what you feel is right for you…….
I personally take .05MG of Levothyroxine nightly for my hypothyroidism and take CBD oil in the day time and afternoon if needed. Usually a few times a month but I once used it for 2 weeks straight everyday. I didn’t notice any I’ll side effects but I only used enough to get the relaxed feeling. My friend also uses it almost daily and said he heard it was safe for me to use it. It’s all I know my doctor knows I use it also. I figured to be safe I don’t take one next to the other. My prescription gets a good 8+ hours to work as I sleep without any other supplements competing then when I wake I take it as needed. I have combined them at night on a few occasions but don’t like to risk the CBD effecting my thyroid meds.
Again nothing scientific here but I use them on the same day. Talk to a doctor for professional advice. My doctor doesn’t know much about CBD from what I gather.
Hi there, my name is Dave and I also take klonopin along with other various medications for siezures, depression anxiety etc. I personally can say that I have not had any significant issues. Yes, you are very wise to check with your doctor. It can and will help with your intake of opiods as you will discover that you will find you do not need to take so many, and you can eventually stop taking it (opiods) if you do it correctly. This does not happen overnight but it does also depend on the type of water (CBD) you consume. I’ll try to keep up with you and help in any way I can. You can become free of opiods with a regiment of water, combinations with the oils you can purchase. Talk to your doctor and try to read as much about it as possible.
I’m looking for the answer to this also. I took it yesterday and had no reactions. Have you tried it?
I am weaning off of Xanax & awaiting my very 1st bottle of CBD Oil. Now I’m just concerned if I can use the CBD Oil with Xanax in my system??
Is cbd oil safe to take with Norvasc and Benicar?
Can I take CBD with thyroid medications?
I take Opana and Norco for pain from MS, will CBD gummies add to pain reduction, and possibly reducing opioids that make me sick.
Can I take CBD oil with Zoloft?? I have been on Zoloft for almost 10 years 50mg. I just started CBD THC free 500mg. Any input?
Hey I take Klonopin and Zoloft for depression and anxiety as well as Celebrex and Robaxin. I was thinking of trying CBD oil for my psoriatic arthritis pain in my joints and hips. I also had disc replacement surgery last year on my L4 and L5. It helped a lot but I still have back pain thanks to that. I am currently taking opioids as well and would love to drop the opioids permanently as I hate taking them. I plan on talking this over with my pain dr before I do it but can anyone tell me if they have had negative interactions with those prescription meds I listed above? I know not to take this as medical advice. That is for my doctor but I just wanted to know if anyone has used CBD oil with these meds and what the results were for THEM. Also, I feel I am completely out of my depth with CBD oil. I never really even smoked marijuana before except maybe once or twice in my youth many years ago. I’m 46 now. Any help with how I am supposed to figure all this out would be appreciated. I have no idea what I’m doing. Thanks.
I’ve been taking a tincture of 3000 mg and its high potency so it’s 50 mg of CBD per milliliter. Now I can tell that it’s really strong and I know that my metabolism is very very slow.
I take it 6 hours before I want to go to sleep but I can’t tell if it helps me or not for sleep…but…the next morning while I’m working I tend to nod off and this is after taking anywhere from 200 to 400 mg of modafinil which is helpful if you are fatigued all the time and since I have to take things to help me sleep I also have to take things to help me stay awake… as crazy as that sounds it’s just something I have to do right now so just go with it…
Normally it takes me a lot longer to process things than anyone else I know because I am overweight and even though I’ve lost weight I still have a ways to go and my metabolism is very very slow but I don’t understand if this is supposed to be out of my system within 12 hours why am I tired from the 7:00 a.m. to 4:00 p.m. and even longer???
It’s aggravating. I need to be fully functional. I should be wide awake with 400 mg of Modafinil/Provigil
Especially after 12 full hours or more…is it possible that it takes my body 12 hours to process this cbd oil?
I’m not even taking any tonight because I’m so tired of being tired yet never able to get good sleep even with taking the CBD at 5pm…. what do I do?
My dads doctor told him absolutely not. He wanted to take it because of the pain he is getting from the Eliquis, so my brother bought him some. Before starting it he consulted with him. That’s my 2 cents worth. Good luck
Would that include low dose (81 mg) of asprin?
First of all, benzodiazepines like Ativan and Xanax are not metabolized through the liver. It’s metabolized through the kidneys. It’s OK to take CBD with benzodiazepines, however, it can increase the drowsiness. You didn’t list one big one: Tylenol or acetaminophen.
My mother is 92 yo. She has pain from a herniated disk and has arthritis. She takes Tylenol w/codeine for pain. As well as her blood pressure meds. She has had several cortisone shots that haven’t really helped. Would she be able to take 150mg cbd oil without complications or what would your recommendations be. Thank you
Apixaban uses 3A4, CBD inhibits it. Therefore, it will increase the anticoagulant effect of Eliquis, which can be very serious. Eliquis has a ‘moderate’ interaction warning for 3A4 inhibitors. I’d be very careful. Consult your doctor.
All antidepressants are fairly intense inhibitors of numerous enzymes. So I would be very careful. But you can reduce the dose of the Zoloft.
Both drugs are excreted via the kidneys, rather than the kidneys, and so I would not expect any negative interactions.
Yeah. Both CBD and both BP meds are 3A4 inhibitors. That means they are boasting each other. So, too much BP med often causes orthostatic hypotension, which your BP crashes when you get up. But that also means that you can lower the dosage of the other BP’s, if you take the CBO consistently.
Most drug interactions are in the 3A4 enzyme. You have no problems there. But candesartan is a strong inhibitor of 2D6. CBD is an inhibitor of 2D6. So, yes, they will boast each other. But you have several options. 1) Use CBD as a boaster, and lower you dose of candesartan, 2) take one in the morning, one in the evening; or 3) Irbesarten is a moderate inhibitor of 2D6. Losartan, Telmisartan, Valsartan and Eprosartan do not used 2D6.
I’m currently taking Trazodone 50mg is it safe to take cbd oil or replace Trazodone for cbd?
I need to know if Eliquis twice a day and CBD oil are compatible.
I have been taking full spectrum Hemp CBD oil (1000mg)(Green Gold CBD) sublingually for two months, a daily dosage of 50mg. I had no noticeable side effects. The other morning I took 100 mg to see if it changed anything with respect to some back pain I was experiencing. At lunch I had explosive diarrhea which lasted for several hours. It went away over night. Today, I went online and learned that 10% of CBD get similar problems.
The other thing is that I’m 79 and use 81mg of aspirin daily since I had a heart attack 17 years ago when two stents inserted. I’m very active, eat healthily. Should I be concerned about CBD and blood thinners?
I tried the CBD oil and it made me feel horrible. My lungs felt sluggish and uncomfortable, my whole body felt tense and strained and my skin had a buzzing crawling feeling. Why would I feel like this when so many others swear by it? It also gave me no relief from any pain that I’ve been having for so very long.
Can i take CBD when taking nalitinib for leaukemia
Does CBD .interact with keppra Lisinopril and labetol
From what I’ve experienced, no. That list above is pretty thorough. I’ve recently tried CBD, and then found out that 5 of my 6 meds are on the list.. I’m still trying to feel the way I did before the CBD. I’m 66yrs old… not a pleasant experience.
I am taking Lecalpin 10 mg a day for blood pressure. Is it of to take CBD Oil with this medication?
I’d like to know the answer to the too I take levothyroxine too 125 mg a day.
If you scroll up, there is a reply from customer care that states you need to check with your own medical providers.
Hi can I take CDB oil with codeine
i am on steroids for auto immune disease and been on it for four months. I SEE NOTHING as far as interfering. Honestly they don’t know. I read yes it does and then i read no it does not. It has helped me sleep pain not so sure but sleeping and anxiety. I do not take it during the day. The list pretty much includes all drugs…Honestly come on…My pharmacist is very helpful more so than doctors about drugs. I take capsules fro Charlotte’s Web…Do your research The best to all of you that suffer. Not easy.
you can buy CBD with Melatonin from Charlotte’s Web or CBDMD …I use CBD capsules one before bed. It calms me and i sleep now 7 hours a night for sure …I have been taking it for a month. Best to you
Pharmacy or doctor can run the drug interaction check program
Will CBD oil affect when taking Lisinopril, Mobic and Calan SR and Antivert Thank you
I just had surgery on my ankle- I fractured my ankle bone. I am prescribed aspirin 325 MG 2x a day to prevent blood clot. Will CBD Oil interact with the aspirin? Is it safe to take the cbd while on aspirin?
Is cbd oil safe to take with Lupron-(hormonr shot)
can i use cbd with warfarin
Can you take CBD oil while taking methotrexate and prednisone?.
I too would like to know. I take 2.5 eliquis
I take levothyroxine, Lisinopril, Omeprazole,ranitidine, and dulexotin. How is taking CBD going to affect these meds?
Can i use CBD oil with my medication. I take 2-100mg. of sertraline for depression in the morning everyday,.-1-.o5 or 2 pills of larazapam as needed for anxiety,and quetiapine 200mg at bedtime everyday.
I just read that Prednisone is one of the steroids that IS NOT affected by CBD. I recently had my 4th steroid epidural and asked my Dr. at Mayo Clinic. He said it would be no problem. So I’m using my tincture right along.
What about using opioids with CBD oil? I don’t see anything specific on this issue. If one is taking pain medications in pain management setting will taking CBD oil upset the pain drugs being effective? Will the CBD oil cause the urine screen to kick it out as a unapproved substance?
I take Ativan at night.metropalol 25 mg a day have great pains from arthritis. Thanks
CBD oil can cause lower blood pressure so monitor your blood pressure when taking both.
My mother in law is on Warfarin and we talked with her heart doctor before starting it as CBD is a natural blood thinner, he was ok with her taking it but he said to not take it within 2 hours of her warfarin and he monitors her INR weekly. Since taking it her warfarin dose has been decreased.
When I started CBD oil the first thing I noticed was I was sleeping twice as much as before. I have always had trouble sleeping and was on medications for it, I don’t need anything anymore but CBD oil to sleep now.
I have been taking CBD oil for 17 months now and I took it two hours of all my other medications including B/P pills and within a couple months I was off all my medications.
Make sure what ever CBD you use is GMP (Good Manufacturing Practice) and 3rd party lab tested. Very few can claim that.
I take alprazolam ER 0.5 mg 2x daily, and atenolol 25 mg x daily can I use CBD oil all spectrum it’s 250mg per 1oz bottle. Already consulted with my primary MD he said it’s ok. But I’m kind of scared as to not really explaining why it’s ok.
I take Xarelto, and will for the rest of my life, and I vape CBD oil with THC and have not had any side effects but I am not a Doctor.
I would also like to know this did you get an answer? I take 2.5mg twice a day
I take Olmesartan 20mg per day. I’ve read that there is a drug interaction with CBD and this drug. Does the CBD stop this drug from working or does the CBD lower the blood pressure further?
It’s a very relaxing feeling. Great for insomnia. Just don’t drive, you might not be fully alert.
Kathryn- it says in the article ( in the section about drug interactions) that benzodiazepines interact with CBd. It just makes you more tired is all
Thanks very nice blog!
Does CBD oil cause lightheadedness when taken with lisinopril and nifedipine?
Yes to all interactions should be the assumption, I have expirenced very negative side fxs , always chk with your doctor before,or just tread very lightly,until you have your answer,
While CBD is def a wonder for a great many conditions….the drugs interactions with meds that are used to treat the conditions could be serious.
I’m taking brilinta I have a stent can I take CBC oil
Steroids are listed above for meds that can interact negatively. Yes steroid shot and cbd are not recommended together. I just started 60 mgs prednisone so I am not using cbc oil until I’m off steroids. Safety first?
You should never take CBD with any blood thinning medication with out consulting your doctor first,
Will CBD interfere in any way with the gabapentin????
I take 250 mg of lamictal 2x daily for bipolar 2 and lacmictal for essential tremor 50mg 2x daily. Are CBD gummies safe and if so, in what dosage?
Does Eliquis and CBD oil work together?
I’m wondering how you went with cbd oil
I also take it
But as yet
Not much happened for depression
I feel better on tramadol
Please let me know how you went
Are there any effects when mixing CBD and Melatonin?
I take Levothyroxine 88mcg and Metformin 500mg 2xa day is it safe to take Hemp CBD oil?
can I take CBC oil and gabAPENTINE
The article says not good. Check with Dr
Hi Donna and Linda,
I’m on Cipralex. Can I safely take cannabis oil for my arthritic shoulder? or will it mess with my head?
Hi, I just purchased a 1000mg CBD Oil Tinicture. I am also a vaper using a 70% vg/ 30% pg nicotine e-juice. Can I still administer the tinicture once in the morning and once at night and still vape during the day?
I am on levothyroxine and warfarin , my INR went up to 3.5 , been in range of 2.3 – 2.7 , started using prescribed CBD oil for pain a month ago. Is this a concern? Prone to blood clots.My GP is not all that up on it – I am teaching him .
I tried it with the warfarin, and it caused a increase in inr, adjusted the warfarin
Can i take CBD oil with riveroxaban?
Please let me know if antibiotics interface w/cb d oil.
JMW- so did they say that the CBD oil only impacts the liver enzymes while it is being absorbed, few hours, or all the tie once youstart taking it? ANy links to where you researched?
Can I take CBD oil with warfarin
Can I take CBD oil with Eliquis
can I use cbd oil with zoloft
I take synthroid and “CTFO” CBD Oil everyday….no problems.
Since we are not licensed practitioners or doctors, so we are not legally able to answer that question. Cannabinoids like CBD may interact with prescription drugs, dietary supplements, and over-the-counter drugs. Always check with your licensed physician or prescribing doctor before using CBD if you are concerned. Also, a holistic doctor or someone in the Chinese medicine field might be able to answer some of your questions and be more versed in the land of CBD. I have attached a link that can help provide a bit of information as well. I can also provide you with an awesome link to connect you with a doctor who specializes in this and can provide a more personalized recommendation for you.
Hi, Since we are not licensed practitioners or doctors, so we are not legally able to answer that question. Cannabinoids like CBD may interact with prescription drugs, dietary supplements, and over-the-counter drugs. Always check with your licensed physician or prescribing doctor before using CBD if you are concerned. Also, a holistic doctor or someone in the Chinese medicine field might be able to answer some of your questions and be more versed in the land of CBD. I have attached a link that can help provide a bit of information as well. I can also provide you with an awesome link to connect you with a doctor who specializes in this and can provide a more personalized recommendation for you.
Drugs that May Interact with CBD Oil: https://cbdoilreview.org/cbd-cannabidiol/cbd-p-450-enzyme/
I take 50mg of tramadol 3xs a day for the past 8 years. Can I use cbd oil in conjuction with them?
Do you know if I can use cbd oil while taking
I also take antihistamines
does it negatively react to eliquis, metoprolol tartrate, or benicar?
Was wondering if CBD salve that i currently use on my shoulder for torn rotator cuff is ok to use every day? I have Afib and take medication for it as well as having very controlled blood pressure and cholesterol with meds. Shoulder feels almost painfree with the salve. What should i be aware of or avoid. CBD salve is the only releif i found.
hi my wife takes BENDROFLUMETHIAZIDE 2.5 mg and SIMVASTATIN 10 mg she has CRONES inflermation bowel . would she be able to try this cbd oil please fingers crossed.thank you THOMAS.
Is is safe to take CBD and synthroid at the same time?
I don’t see an answer to this: Can I take CBD oil with Eliquus?
There will be negative interactions. It’s metabolized through the same liver enzyme and will most likely cause additional side effects (headache) and reduced effectiveness of both the drugs.
Can i use Cbd oil if ive had steroid injections.
I’m taking lofrapamine 140 daily for anxiety and depression plus thyroxine will cbd interact
can i take it with antibotics and tylenol?
What kind of reaction or results could occur if I take CBD oil
when I am on Cardiazem, Cozaar and Omeprazole?
I am wondering if CBD oil can be taken with Concerta 54mg, and Fluoxetine 40mg.
Hi Janet. I too take levothyroxine and losartan hctz. I did some research and after talking to a provider was told and read that your levo should be taken 2 hours before CBD oil. BP meds should also be separated by a few hours just to be safe. Peace!
Can I take CBD oil with gabapentin?
my parents are taking blood pressure meds, and other prescribed medications such as enalapril, atenolol, metformin, omeprazole, temazephan oxycodone, warfarin, and others, will any of these meds interact with CBD oil?
Will CBD OIl be safe to take if i take the medications tamoxifen, lisinoprul/hctz,ambien, lexapro, 81 mg aspirin daily, and adderal 20 mg and XR 20 ?
I take amlodapine and allegra with .50 Cbd oil twice daily. I get lots of burning pain lying down and sitting up. Is it the interaction with cbd?
Can CBD interfere with taking a procrit shot
I am taking clonazepam 5 mgs per day can I take cbd with this.
Hello, I am taking clomipramine for ocd, can I safely use cbd oil, mainly want to try it for back pain.
Can CBD cream be used while taking Ibrance (palbociclib)? Ibrance is used for women who have metastatic breast cancer, Estrogen positive. Because I am ER+ I need to make sure to avoid THC.
I take omeprazole, lizess, bupropn, chlordiazepox-clidinium, venlafaxine, and triazolam. Any side effects
Hello. I have HIV and Hepatitis B. I’m on daily prescription dosage of Atripla, and still take the 10 drops of Hempworx every night before bed. I have been feeling well, much better in fact, but I would like to know the interaction, if any , CBD oil has on my medication.
Can you take Ritalin and cbd oil on the same day? I have add, but also anxiety so I thought about trying cbd oil.
Hi! I’m taking levothyroxin and hydrochlorathiazide. Will CBD oil interfere with those?
I take Lexamil, a generic of cipralex and much cheaper here in South Africa. I have started using CBD vape and so far have had no side effects. I just ensure that I do not vape an hour either side of ingesting Lexamil.
Hi I am Tom Mac 12 month ago I had the top of my lung removed with cancer 6month later I got the all clear 6 month later I am told I have a shadow on both lungs can I take cannabis oil with my medication rivaroxaban and diltiazem hidrocloruro.
Can I take cbd oil with a stop smoking aid? Chantix
Does CBD oil thin the blood
I take eliquis, flecainide,bystolic,furosimide androsuvastatin.
I would like to take two drop of CBDoil to help me sleep better.
I’m concerned about possible interactions.
Hey can one take cbd alongside thyroxene? my mother taking cbd for alzheimers and osteo arthritis pain relief but wakes up in great pain in the morning and then has to wait half an hour to take the cbd. the cbd is working very well otherwise
I have Parkinson’s disease , and would like to use CBD oil but I don’t know if it will interfere with my medication. I take Adcal, Ferrous fumarate , Levothyroxine sodium 25 micrograms , Levothyroxine sodium 50 micrograms, and Madopar. If you can reassure me about this i would be grateful. Thankyou Mrs Christine Smith.
I take Lamictal for seizures and Lorazapham for anxiety. Can i still take hemp oil ?
Can I take Eliquis and CBD or Hemp Oil together?
I am taking endep, lyrica &topamax, is it safe for me to use the hemp oil spray while on these medications.
Are there any side effects with taking 75 mg of voltaran twice daily and 15 mg of cbd oil also twice daily. If so what are they?
I am taking rivaroxaban can I take cbd oil?
Is it safe to take Allegra for my allergy symptoms while using CBD for anxiety and migraine?
I heard that CBD oil should not be used if you are on statin medications for cholesterol. Is this true?
Does CBD oil have any interactions with hydrocortisone or metroprolo?
I have Addison’s disease and have to take hydrocortisone daily 25 mg
What is the interaction concern between CBD oil and Losartan if any?
Hey Margaret, the article outlines that CBD does interfere with NSAID use. If you do take them together, separate the dosage timing.
Did you ever receive a reply to this? I need to know about these meds too
Where are the replies from the physician/ pharmacist???????
I’d like to find answers.
I am currently taking:
Anoro Elipta – daily
Flutucasibe Propionate Nasal Spray (Flonase) daily
Sotalol 40 mg.
Eliquis 5 mg.
Levothyroxine 80 mg.
Gabapentin 300 mg. as needed
Wonder if CBD oil would be okay to take along with these medications?
Will patients that have had organ transplants and are taking immunosuppressive drugs have issues with CBD oil?
I have type two diabetes. I take enelapril,levothroxin,gemephibrozil,renidadin and metformin. I started taking 250mg cbd. Will cbd interact with my medication
Can you take cbd with. Valsartin and eliquis
I take 6 MG of warfarin daily, taking the CBD oil would there be a problem?
Can I take the Holland and Barrett CBD OIL 2.75% with naproxen diazepam and amytriptaline and prozac
Can cbd thc tincture be taken with
Hi, Does anyone know if you can take cbd( thc free) with cipralex
Can this oil help with pulmonary fibrosis of lungs & abscesses in them toon
*Does CBD interact with Alpha Blocker Doxazosin*
Does CBD interact with Alpha Blocker Do
I take several medications and I need to know if any of my medications will not work with this method of pain reliever. I am getting ready for a shoulder replacement in September. I have Osteoporosis arthritis. I have had both hips replaced and my left shoulder. My sister says that this really works, but I just need to know how it will work with my meds. Thank you
Hi, I take 75ml asprin each day. Is it safe to also take Hemp oil?
Many thanks for your time.
I am taking clonezepam at night and 50 mg of trazedone. also take omneprezal and drugs for copd. Can I take CBD oil with these drugs? Also asking about my granddaughter who is 32 and taking respadal and clonezepam. Could she take CBD oil and maybe lessen the drugs she is on as they make her sleepy all day?