What is Clinical Endocannabinoid Deficiency Syndrome?
Clinical Endocannabinoid Deficiency (CECD) is a condition where an individual produces a lower amount of cannabinoids than experts consider to be essential in the promotion of health, vitality, and well-being.
Scientists now believe CECD may play a role in the following conditions:
What Are Endocannabinoids?
Human, reptiles, birds, and fish all synthesize endocannabinoids (research is still being done on invertebrates) naturally. In fact, the prefix “endo,” literally means “made in the body.”
Endocannabinoids are part of the more extensive endocannabinoid system that regulates appetite, pain sensation, mood, memory, and so much more.
There are three essential parts to the endocannabinoid system:
How Does the Endocannabinoid System Work?
Enzymes regulate the endocannabinoid system by stimulating the synthesis of endocannabinoids in order to raise their levels or signal their destruction in order to reduce their levels.
Endocannabinoids are lipids, which are a particular type of fat that interacts with the nervous system to cause specific changes in the body.
Endocannabinoids latch onto individual endocannabinoid receptor cells to make these changes in the nervous system happen. All mammals produce endocannabinoids that bind to endocannabinoid receptors.
Endocannabinoids act in contrast to more well-known neurotransmitters such as serotonin, dopamine, and norepinephrine.
Dopamine, for example, is synthesized in advance, stored in the vesicle, and then released (in response to stimuli) from the presynaptic cell, where it crosses the synapse, lands on the postsynaptic cell, and causes activation.
Endocannabinoids, on the other hand, are integral components of cellular membranes that we appear to manufacture on demand. As they are hydrophobic, they cannot travel very far in the body and exert only local effects.
This limited effect contrasts with things like hormones, which reaches farther and impacts the whole body.
Endocannabinoids also travel backwards. The begin by leaving the postsynaptic cell and end at the presynaptic cell where there are high concentrations of axons which release conventional neurotransmitters.
This allows the postsynaptic cell a ‘flow control’ of sorts, enabling endocannabinoids to mitigate the flow of neurotransmitters coming from the presynaptic cell.
There are two main types of cannabinoid receptors, CB1 and CB2; CB1 receptors are most highly concentrated in the brain, while CB2 receptors are primarily in the immune system.
In the brain, these CBD receptors are found to have the highest concentration in the limbic system. The limbic system is not a separate part of the brain but is a collection of the hippocampus, hypothalamus, piriform cortex, amygdala, and more.
Benefits of activating the CB1 receptor can include:
- Relieving depression [S]
- Increasing myelin formation [S]
- Lowering intestinal inflammation [S]
- Decreasing intestinal permeability (Leaky Gut Syndrome) [S]
- Lowering blood pressure [S]
- Lowering anxiety [S]
- Reducing fear and paranoia [S]
- Increasing BDNF levels [S]
- Increasing PPARy expression [S]
- Reducing GPR55 signaling [S]
- Lowering prolactin [S]
First discovered in 1993, CB2 receptors occur most commonly in the spleen, tonsils, thymus, and immune cells such as mast cells, monocytes, macrophages, B and T cells, and microglia. Only a small number of these receptors exist in the brain.
Activating the CB2 receptor induces macrophages to destroy beta-amyloid protein — the primary component of the amyloid plaque found in the brains of people with Alzheimer’s disease. This may help explain why there is research underway to try and determine if CBD can help Alzheimer’s patients.
Changes in CB2 receptor function happen are not unusual and can happen with nearly every type of human disease whether they are cardiovascular, gastrointestinal, neurodegenerative, psychiatric, autoimmune, or pain-related illnesses. [S] The better we can understand this system, the better we can understand what happens in our bodies and how to find relief and functionality.
The Magic of Phytocannabinoids
Some plants, cannabis, in particular, produce a substance similar to endocannabinoids that interact with our body’s cannabinoid receptors. These phytocannabinoids, literally plant-made cannabinoids, can have a profound effect on the body. While there are many plants that produce substances that act upon cannabinoid receptors, the cannabis plant is the only know to produce cannabidiol (CBD).
Other plants containing cannabinoids include:
- Kava (Piper methysticum)
- Black Pepper (Piper nigerum)
- Rosemary (Rosmarinus officinalis)
- Liverwort (Radula marginata)
- Helichrysum (Helichrysum umbraculigerum)
- Electric Daisy (Acmella oleracea)
- Echinacea (Echinacea purpurea)
- Cacao (Theobroma cacao)
- Truffles (Tuber melanosporum)
When phytocannabinoids interact with our body’s endocannabinoid receptors, they often have a therapeutic effect – improving the overall functioning of the endocannabinoid system.
Excessive or deficient endocannabinoid levels can cause body systems to perform poorly, as can be seen by the cluster of illnesses believed to have a root in CECD.
Endocannabinoid Deficiency, CBD Oil, and Migraines
Research published in Neuroendocrinology Letters reviewed scientific publications to study the concept of CECD and the possibility that endocannabinoid deficiency can cause migraines.
This study found that anandamide controls the receptors associated with migraines and that this endocannabinoid strongly influences the periaqueductal gray matter – an area known as the “migraine generator” in the brain.
The researchers also found cannabinoids block spinal, peripheral and gastrointestinal actions that promote the pain associated with headaches, fibromyalgia, irritable bowel syndrome and other conditions.
In other words, increasing cannabinoid levels may reduce symptoms associated with clinical endocannabinoid deficiency syndrome.
By inhibiting FAAH, CBD is known to boost anandamide levels in the body.
Other ways which CBD may assist with migraines include:
- Activating the 5-ht1A Receptor (at high doses): The 5-ht1a receptor helps regulate anxiety, addiction, appetite, sleep, pain perception, nausea, and vomiting. CBDA (the raw form of CBD) shows an even higher affinity for this receptor than CBD. [S]
- Antagonizing GPR55 Receptors: GPR55 receptors are widely distributed in the brain (especially the cerebellum) and help control bone density and blood pressure. Additionally, GPR55 promotes cancer cell proliferation when activated. These facts may explain CBD’s use by individuals with osteoporosis and high blood pressure. [S]
- Activating TRPV1 Receptors: Involved in regulating pain, body temperature, and inflammation. Substances targeting TRPV1 receptors include anandamide, AM404 (a metabolite of acetaminophen), capsaicin, and various cannabinoids such as CBN, CBG, CBC, THCV, and CBDV.
How To Use CBD Oil for Endocannabinoid Deficiency
It would be great if we could you one number and say is the perfect amount for consumption across the board, unfortunately, it doesn’t work that way. There are many factors that go into deciding on the ideal serving size and it would be irresponsible to ignore these variations between individuals.
While it is not as ideal as a single number, we at CBD Oil Review (COR) have done an extensive analysis of hundreds of products that has lead us to develop an official COR Serving Standard.
The COR Serving Standard is 25mg of CBD, taken twice daily.
If this amount does not have any impact, our analysis also suggests increasing the amount of CBD you are using by 25mg every 3-4 weeks until you have found the results you are after.
Similarly, if your condition gets worse, reduce the amount you are using by 25mg until you find the right balance.
You can refer to our page on serving size for CBD for additional information.
As always, before you start any natural supplementation regime, please consult with your primary care provider to make sure this is the best, and safest, path for you.
Learn More About CBD
CBD oil products are everywhere now, but ambiguity surrounding the use of CBD oil still abounds, especially in the world ...Learn More
Imagine this: you're curled up on your comfortable couch, surrounded by soft throw pillows, sipping a cup of hot chocolate ...Learn More
Though many people are still learning about cannabidiol (CBD) and its many natural benefits, the naturally occurring chemical compound has ...Learn More
A lot of people ask this question - is CBD oil legal in Florida? It appears that there has been ...Learn More
If you're just starting to learn about CBD and its potential benefits, you likely have many questions. There is so ...Learn More
Every plant on the planet has a purpose. Every piece of the ecosystem serves a purpose, and some lucky plants ...Learn More
For decades, people have been raving about the endless benefits of the hemp plant. Surprisingly though, some people may still ...Learn More
I’ve been poking around the interweb a bit for travelling with CBD tips and was a little surprised… I think ...Learn More
Delta 8 THC is the hot new cannabinoid on the wellness scene. As was the case with CBG a couple ...Learn More
The term ‘seed to sale’ is thrown around a lot in CBD marketing. CBD companies that claim to be seed ...Learn More
Delta 8 THC is one of the many cannabinoids found in the hemp plant. Like cannabidiol aka CBD oil, delta ...Learn More
We don’t have to tell you. You already know that CBD oil is one of the most important wellness discoveries ...Learn More
Hemp CBD has a confusing history of legalization that it shares with its intoxicating cousin, marijuana. Both the federal and ...Learn More
Like many people, it is likely that you have seen an increase in the popularity of CBD in the last ...Learn More
These days, it seems like everyone is talking about CBD oil and the benefits it can provide. Yet, if you ...Learn More
If you are interested in using CBD oil, but you live in Tennessee, you may have a lot of questions ...Learn More
Although the CBD industry continues to grow by leaps and bounds, many people interested in the cannabinoid's therapeutic potential are ...Learn More
If you live in Virginia, and you are interested in buying CBD oil, you may be wondering several things. For ...Learn More
CBD oil products have come to the forefront of discussions about non-traditional solutions to anxiety, pain, and other ailments that ...Learn More
CBD oil products have gained popularity in Michigan and across the nation because of the potential benefits they offer consumers ...Learn More
For fans of soccer (or football as most of the world calls it), there is likely a lot of speculation ...Learn More
A hemp flower is the most basic form of CBD and serves as the foundation for all other CBD products ...Learn More
The safety, legality, and absence of mind-altering properties make cannabidiol (CBD) a popular choice for those who want to reap ...Learn More
Between 2021 and 2027, the weight loss industry will benefit from a compound annual growth rate (CAGR) of 10.6%. As ...Learn More
If you live in Ohio and you are curious about using CBD, you may have a lot of questions. For ...Learn More
Cannabidiol (CBD) is one of more than 100 active compounds found in the cannabis plant. CBD oil manufacturers extract cannabidiol ...Learn More
If you were to ask a group of CBD enthusiasts for product recommendations, you'd soon discover that CBD users seem ...Learn More
In 2014, when the industry was still quite new, CBD generated nearly 50 million dollars in sales. That's pretty impressive ...Learn More
Industrial hemp was one of the very first domesticated crops, a plant harvested throughout history for its protein-rich seeds and ...Learn More
As you have likely heard by now, CBD has quickly become one of the biggest trends in the world of ...Learn More
Surprisingly enough, there are a lot of misconceptions floating around when it comes to cannabidiol. Cannabidiol, more commonly known as ...Learn More
CBD products are becoming increasingly popular in 2021, and CBD concentrates are no exception. If you've thought about trying CBD ...Learn More
Let's talk self care. Though you might think of self care as simply "pampering" yourself, it goes way deeper than ...Learn More
Texas Governor Abbott signed legislation clarifying which hemp products are legal and which are not. Looking for CBD in Texas? ...Learn More
CBD oil has many helpful-- not to mention, natural-- benefits physically and mentally. CBD has been heavily studied to relieve ...Learn More
If you are an avid runner, you are always looking for safe and healthy ways to improve your performance and ...Learn More
Can you use CBD if you are sober? Recovery from drug or alcohol addiction isn't just about abstinence. For many, ...Learn More
If there's anything we've learned from the last few years of incredible development, it's that the cannabis plant can take ...Learn More
By now, you are probably aware that there are a lot of CBD products on the market that can help ...Learn More
If you have never tried CBD oil and you live in Indiana, you probably have a lot of questions. You ...Learn More
CBD (short for cannabidiol) has become an alternative consideration for many parents around the world. Countless families swear by CBD ...Learn More
Birth control remains one of the greatest biomedical advances in the last century, giving women and couples the opportunity to ...Learn More
When shopping for CBD, it's essential to find the best product for your needs and your lifestyle. While CBD tinctures ...Learn More
For people who are considering CBD or have already started trying what is available, one of the most common questions ...Learn More
CBD oil is well known for its ability to regulate pain and inflammation, making it a valuable tool in the ...Learn More
Cannabinoid hyperemesis syndrome (CHS) is a true mystery. It can pop up out of nowhere for chronic cannabis users, and ...Learn More
When you first begin researching CBD oil, it can be hard to understand what you are reading. What exactly is ...Learn More
Death by overdose has become the largest killer of Americans under the age of 50, and with opioids responsible for ...Learn More
The most famous cannabinoids are tetrahydrocannabinol (THC) and cannabidiol (CBD). THC is most widely known for its mind-altering, high-inducing properties, ...Learn More
Because harvested and dried cannabis or hemp material only contains trace amounts of cannabigerol (CBG), it is often considered to ...Learn More
With cannabidiol (CBD) oil becoming more widely available, it is being sought out by an ever-growing number of people due ...Learn More
In 2018, the United States saw exponential growth in CBD oil product development and sales. Halfway through the year, the ...Learn More
The cannabis sativa plant contains hundreds of cannabinoids, each one presenting its own unique qualities and potential benefits. You may ...Learn More
Cannabinoids have taken over the natural health discussion, and with good reason. Research is continuously finding new ways in which ...Learn More
One of the lesser-known cannabinoids, cannabichromene (CBC) may be able to do some pretty incredible things. Recent scientific study has ...Learn More
Learning about the phytocannabinoids that exist in the cannabis plant family can feel a little bit like sifting through alphabet ...Learn More
Cannabidiol (CBD), is becoming widely used for its reported therapeutic benefits, which include pain reduction, nausea relief, and mood elevation ...Learn More
Tetrahydrocannabinol (THC) is probably the best-known cannabinoid found in the cannabis plant. THC is the psychoactive, intoxicating, and mind-altering compound ...Learn More
Of the many phytocannabinoids found in cannabis plants, tetrahydrocannabinol (THC) and cannabidiol (CBD) are likely the most well-known. That's why ...Learn More
The role of “Big Pharma” in healthcare is a contentious subject and one that’s working its way into discussions around ...Learn More
With more and more research coming out that shines a light on the reported health benefits of CBD and essential ...Learn More
Researchers are finding that CBD oil may be able to treat the symptoms of a whole host of diseases and ...Learn More
When you first decide to use CBD oil, it can be hard to know where to start. With so many ...Learn More
Health supplements are becoming increasingly commonplace as average Americans struggle to meet their recommended daily intake of vitamins and minerals ...Learn More
If you've spent any time reading about CBD oil and cannabis lately, it is likely you've seen terpenes mentioned more ...Learn More
If you’re interested in purchasing CBD oil but aren’t sure if it’s legal in your state, you’ve come to the ...Learn More
The CBD oil industry is one of the fastest-growing in North America and as such, it should come as no ...Learn More
Not long after the first cannabinoid was isolated from the cannabis plant, scientists discovered the human body produces similar substances ...Learn More
Those friendly neighbors on the northern U.S. border have a reputation for being fairly liberal minded. In fact, as of ...Learn More
As people continue to abandon cigarettes, vaping is becoming increasingly popular. And, as the range of vape oils, vape juices, ...Learn More
Ready to make your first CBD oil purchase but aren’t sure where to start? Well, you’ve come to the right ...Learn More
With so many CBD oil products and delivery formats available for purchase, knowing which one is right for you can ...Learn More
The hemp plant produces flowers just like its THC-toting cousin marijuana. Typically, this flower is processed and cannabidiol (CBD) is ...Learn More
CBD oil drops are one of the most popular ways to take cannabidiol (CBD). They are a cost-effective and convenient ...Learn More
If you’re new to the world of CBD oil, there’s a lot of new terminology to take in; one term ...Learn More
Is there nothing cannabidiol can’t do? The wonder compound—more commonly known as CBD—has been hailed as everything from a digestive ...Learn More
As an athlete, the less time you can spend doing online research, the more time you can devote to your ...Learn More
CBD oil microdosing is a concept that gets thrown around a lot these days, but what does it actually mean? ...Learn More
Because CBD oil has also been shown to reduce inflammation and swelling while promoting cell reparation, CBD topicals (e.g. balms, ...Learn More
When investigating cannabis products, it’s easy to become overwhelmed by all the varieties available. Cannabis oil, hemp seed oil, CBD ...Learn More
People are quickly becoming aware of the potential benefits of CBD oil, but this awareness has lead to one very ...Learn More
Today, it’s hard to go a day without hearing something about CBD oil, and for good reason. Cannabidiol (CBD) is ...Learn More
There are tens of millions of Americans who smoke cigarettes and millions of others who are suffering from smoking-related diseases ...Learn More
There are two main types of cannabidiol (CBD) extract utilized by vendors - purified, crystalline isolate, often labeled as ‘CBD ...Learn More
With frequent news reports about newly discovered uses for cannabidiol (CBD) in healthcare, a number of parents are investigating its ...Learn More
There is an increasing amount of coverage in the media about CBD oil and its potential uses and benefits. Everywhere ...Learn More
CBD oil interacts with the brain and central nervous system to produce a number of beneficial outcomes from reducing inflammation ...Learn More
The short answer: Yes...and no. If you’ve been following the national conversation about cannabis, you may have felt confused at ...Learn More
If you’re an athlete or fitness enthusiast who has heard about the many health benefits of cannabidiol (CBD), you may ...Learn More
In an age where a dizzying number of health supplements are readily available for the fitness enthusiast, separating the facts ...Learn More
In recent years, CBD oil has been used to treat certain symptoms of Alzheimer’s disease, including memory loss. This welcome ...Learn More
A growing number of cafes and eateries are advertising CBD-infused coffee and tea on their long list of caffeine offerings, ...Learn More
As cannabis legalization spreads, more and more people are considering cannabis products and wondering how to talk to their doctor ...Learn More
If you’re a close follower of skin and beauty product trends, you may have noticed a rise of CBD oil ...Learn More
As a breastfeeding mother, you know how carefully you need to monitor your consumption. Certain foods and drinks are off ...Learn More
There are several techniques available for extracting CBD oil from the cannabis plant. The two most common are ethanol extraction ...Learn More
CBD shatter is one of the purest forms of cannabidiol (CBD oil) that money can buy and it is completely ...Learn More
One of the first questions asked by people just learning about CBD oil is, “Can CBD oil get you high?” ...Learn More
CBD oil has been praised for its many potential health benefits and its use in the treatment of several chronic ...Learn More